A tight control of intracellular [Ca2+\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^{2+}$$\end{document}] is essential for the survival and normal function of cells. In this study we investigate key mechanistic steps by which calcium is regulated and calcium oscillations could occur using in silico modeling of membrane transporters. To do so we give a deterministic description of intracellular Ca2+\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^{2+}$$\end{document} dynamics using nonlinear dynamics in order to understand Ca2+\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} (...) \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$^{2+}$$\end{document} signaling. We first present the ordinary differential equations system for cell calcium kinetics and make a preliminary work on Sobol indices. We then describe and analyze complex transporters action. Besides, we analyze the whole system. We finally perform numerical simulations and compare our results to real data. (shrink)

This interview, conducted over the span of several months, tracks the respective journeys of Constantin V. Boundas and Daniel W. Smith with the philosophy of Gilles Deleuze. Rather than “becoming Deleuzian,” which is neither desirable nor possible, these exchanges reflect an array of encounters with Deleuze. These include the initial discoveries of Deleuze’s writings by Boundas and Smith, in-person meetings between Boundas and Deleuze, and the wide-ranging and influential philosophical work on Deleuze’s concepts produced by both Boundas and Smith. At (...) stake in this discussion are key contributions by Deleuze to continental philosophy, including the distinction between the virtual and the actual and the very nature of a “concept.” Also at stake is the formative or pedagogical impact of a philosopher, like Deleuze, on those who find and fully engage with his texts, concepts, and project. Cette interview, menée sur plusieurs mois, suit les parcours respectifs de Constantin V. Boundas et Daniel W. Smith avec la philosophie de Gilles Deleuze. Au lieu de « devenir Deleuzien, » ce qui n’est ni souhaitable ni possible, ces échanges reflètent un éventail de rencontres avec Deleuze. Il s’agit notamment des premières découvertes des écrits de Deleuze par Boundas et Smith, des rencontres en personne entre Boundas et Deleuze, et du travail philosophique vaste et in????luent sur les concepts de Deleuze produit par Boundas et Smith. L’enjeu ici étant les contributions clés de Deleuze à la philosophie continentale, y compris la distinction entre le virtuel et l’actuel, et la nature même d’un « concept. » Mais il y a aussi l’impact formateur ou pédagogique d’un philosophe, comme Deleuze, sur ceux qui trouvent et s’engagent pleinement dans ses textes, ses concepts et ses projets. (shrink)

_ Source: _Volume 39, Issue 2, pp 118 - 137 Most of the empirical research in trauma psychology focuses on posttraumatic reactions, rather than on positive outcomes besides increased attention to contributing factors to the concept of posttraumatic growth. The study presented in this paper investigates the role of religious commitment on the one hand and religious and non-religious coping on the other as contributing factors to posttraumatic growth among Internally Displaced Persons in Georgia. Based on data from _N_ = (...) 190 IDP s, Structural Equation Modeling was used to understand posttraumatic growth and the role of religiosity as a coping resource and strategy. Results indicate that religious commitment is not directly related to areas of posttraumatic growth but it has a positive impact on posttraumatic growth when it fosters religious and non-religious ways of coping. Each and every component has shown to have unique contribution to the outcome variable. Finally, implications of the practical value and for the field in general are discussed. (shrink)

Unfounded—conspiracy and health—beliefs about COVID-19 have accompanied the pandemic worldwide. Here, we examined cross-nationally the structure and correlates of these beliefs with an 8-item scale, using a multigroup confirmatory factor analysis. We obtained a two-factor model of unfounded (conspiracy and health) beliefs with good internal structure (average CFI = 0.98, RMSEA = 0.05, SRMR = 0.04), but a high correlation between the two factors (average latent factor correlation = 0.57). This model was replicable across 50 countries (total N = 13,579), (...) as evidenced by metric invariance between countries (CFI = 0.96, RMSEA = 0.06, SRMS = 0.07) as well as scalar invariance across genders (CFI = 0.98, RMSEA = 0.04, SRMS = 0.03) and educational levels (CFI = 0.98, RMSEA = 0.04, SRMS = 0.03). Also, lower levels of education, more fear of COVID-19, and more cynicism were weakly associated with stronger conspiracy and health beliefs. The study contributes to knowledge about the structure of unfounded beliefs, and reveals the potential relevance of affective (i.e., fear of COVID-19) and cognitive (i.e., cynicism) factors along with demographics, in endorsing such beliefs. In summary, we obtained cross-cultural evidence for the distinctiveness of unfounded conspiracy and health beliefs about COVID-19 in terms of their structure and correlates. (shrink)

Historische Praxeologie richtet ihren Blick auf vergangenen Alltag. Ihr Interesse gilt dem historischen Menschen in seinem alltäglichen Tun und Sprechen, das sie in Praktiken verortet. Der Band stellt den historisch-praxeologischen Forschungsansatz programmatisch als neuen Zugriff auf die Kulturgeschichte vergangenen Handelns vor. Praktiken sind erkennbare Muster im vergangenen Alltag. Sie zeichnen sich durch Routinen und Dynamiken, zeitgenössische Logik und Bedeutungszuschreibungen sowie das Mitwirken von Dingen aus. Als Zusammenhänge menschlichen Handelns sind sie bis heute lesbar. Der historisch-praxeologische Ansatz versteht sich als eine (...) Weiterführung von Alltags- und Mikrogeschichte sowie Selbstzeugnisforschung. Mit Beiträgen von M. Böth, J. Breittruck, J. Esch, A. Mariss, J. Cáceres Mardones, T. Neu, A. Raapke, B. Reicherdt und D. Sittler sowie einem runden Tisch mit N. Buschmann, D. Freist, M. Füssel, F. Hillebrandt und A. Landwehr. (shrink)

Unfounded—conspiracy and health—beliefs about COVID-19 have accompanied the pandemic worldwide. Here, we examined cross-nationally the structure and correlates of these beliefs with an 8-item scale, using a multigroup confirmatory factor analysis. We obtained a two-factor model of unfounded (conspiracy and health) beliefs with good internal structure (average CFI = 0.98, RMSEA = 0.05, SRMR = 0.04), but a high correlation between the two factors (average latent factor correlation = 0.57). This model was replicable across 50 countries (total N = 13,579), (...) as evidenced by metric invariance between countries (CFI = 0.96, RMSEA = 0.06, SRMS = 0.07) as well as scalar invariance across genders (CFI = 0.98, RMSEA = 0.04, SRMS = 0.03) and educational levels (CFI = 0.98, RMSEA = 0.04, SRMS = 0.03). Also, lower levels of education, more fear of COVID-19, and more cynicism were weakly associated with stronger conspiracy and health beliefs. The study contributes to knowledge about the structure of unfounded beliefs, and reveals the potential relevance of affective (i.e., fear of COVID-19) and cognitive (i.e., cynicism) factors along with demographics, in endorsing such beliefs. In summary, we obtained cross-cultural evidence for the distinctiveness of unfounded conspiracy and health beliefs about COVID-19 in terms of their structure and correlates. (shrink)

Early in the fourth century Constantine made Christianity the religion of the Roman Empire, and at once had reason to regret his having done so; for now not only the Church but the state was convulsed by controversies about the Holy Trinity. These controversies raged for over two hundred years, after which the bishops found new intellectual outlets, if not more rational ones, for their animosities. But Trinitarian trouble was not dead, only sleeping. The Great Schism of the eleventh (...) and twelfth centuries, which split the Western from the Eastern Church, took place, on its theological side, over a question concerning the Trinity. This was, of course, that most famous of all theological questions, the question of the procession of the Holy Ghost, or of the filioque. The Orthodox theory was that the Holy Ghost proceeds from the Father alone. The Western bishops, however, were equally adamant that the Holy Ghost proceeds from the Father filioque - 'and the Son'. (shrink)

En dépit des réformes dites libérales des années 1860, l'Empire russe resta tout au long du XIX e siècle un empire dont le souverain s'intitulait officiellement : « Tsar et Autocrate de toutes les Russies ». L'autocratie différait fortement de la monarchie française d'Ancien Régime, qu'embarrassaient et que contenaient mille traditions et reliques du passé : droit coutumier et droit romain, vieilles lois de sources diverses toujours en vigueur, privilèges, prérogatives, immunités, franchises, exceptions et exemptions, Église indépendante, etc. Dans le (...) système russe du « césaropapisme », l'empereur faisait également office de souverain pontife de la religion orthodoxe : il en était le « défenseur et gardien ». - En 1881, le tsar Alexandre II fut tué dans un attentat, alors que l'octroi d'une Constitution semblait imrm'nent. Son règne avait été marqué par une série de réformes, dont la plus célèbre (1861) est celle qui avait émancipé les paysans serfs. Constantin Pétrovitch Pobedonostsev (1827-1907), célèbre juriste et homme d'État russe, qui avait été le précepteur des fils d'Alexandre II, va alors devenir le principal représentant d'une politique de contre-réformes, d'une politique refusant que soit faite la moindre concession aux idées libérales. Nommé par Alexandre III procureur du Saint-Synode, il exercera une influence prépondérante en Russie pendant la première partie du règne de ce tsar (c'està-dire de 1881 à 1887). Certains de ses écrits, pamphlets ou manifestes ont été réunis dans un Recueil de Moscou, paru en 1896. Nous y verrons Pobedonostsev dénoncer une à une toutes les institutions qui pourraient, si jamais elles étaient importées d'Occident, limiter les prérogatives du tsar autocrate : séparation de l'Église et de l'État ; suffrage universel et discours sur la prétendue souveraineté du peuple ; instruction gratuite et obligatoire, impliquant une limitation du travail des enfants ; liberté de la presse et invocation constante de l' « opinion publique » ; institution (à l'anglaise) de jurys populaires dans les tribunaux. - Mais nous aurons la surprise de trouver également, dans ce même Recueil de Moscou, un catalogue très raisonné des principales « pathologies » qui, selon Pobedonostsev, accompagnent nécessairement un régime de démocratie représentative : corruption des représentants ; combinaisons et tractations incessantes entre les partis ; indifférentisme massif et hypertrophie du moi personnel chez les électeurs ; omniprésence d'une presse dépourvue de tout mandat électif et parlant cependant au nom du public ; etc. Un tel catalogue constitue à n'en pas douter ce que l'œuvre de Pobedonostsev, ce réactionnaire « sur toute la ligne », contient de moins inactuel. (shrink)

Gilles Deleuze: The Intensive Reduction brings together eighteen essays written by an internationally acclaimed team of scholars to provide a comprehensive overview of the work of Gilles Deleuze, one of the most important and influential European thinkers of the twentieth century. Each essay addresses a central issue in Deleuzeʹs philosophy (and that of his regular co-author, Félix Guattari) that remains to this day controversial and unsettled. Since Deleuzeʹs death in 1994, the technical aspects of his philosophy have been largely neglected. (...) These essays address that gap in the existing scholarship by focusing on his contribution to philosophy. Each contributor advances the discussion of a contested point in the philosophy of Deleuze to shed new light on as yet poorly-understood problems and to stimulate new and vigorous exchanges regarding his relationship to philosophy, schizoanlysis, his aesthetic, ethical and political thought. (shrink)

Due to Gӧdel’s incompleteness results, the categoricity of a sufficiently rich mathematical theory and the semantic completeness of its underlying logic are two mutually exclusive ideals. For first- and second-order logics we obtain one of them with the cost of losing the other. In addition, in both these logics the rules of deduction for their quantifiers are non-categorical. In this paper I examine two recent arguments –Warren (2020), Murzi and Topey (2021)– for the idea that the natural deduction rules for (...) the first-order universal quantifier are categorical, i.e., they uniquely determine its semantic intended meaning. Both of them make use of McGee’s open-endedness requirement and the second one uses in addition Garson’s (2013) local models for defining the validity of these rules. I argue that the success of both these arguments is relative to their semantic or infinitary assumptions, which could be easily discharged if the introduction rule for the universal quantifier is taken to be an infinitary rule, i.e. non-compact. Consequently, I reconsider the use of the ω-rule and I show that the addition of the ω-rule to the standard formalizations of first-order logic is categorical. In addition, I argue that the open-endedness requirement does not make the first-order Peano Arithmetic categorical and I advance an argument for its categoricity based on the inferential conservativity requirement. (shrink)

Considered one of the most important works of one of France's foremost philosophers, and long-awaited in English, _The Logic of Sense_ begins with an extended exegesis of Lewis Carroll's _Alice in Wonderland_. Considering stoicism, language, games, sexuality, schizophrenia, and literature, Deleuze determines the status of meaning and meaninglessness, and seeks the 'place' where sense and nonsense collide. Written in an innovative form and witty style, _The Logic of Sense_ is an essay in literary and psychoanalytic theory as well as philosophy, (...) and helps to illuminate such works as _Anti-Oedipus_. (shrink)

This paper seeks to develop a phenomenological account of the disorientation of grief, specifically the relationship between disorientation and the breakdown in practical self-understanding at the heart of grief. I argue that this breakdown cannot be sufficiently understood as a breakdown of formerly shared practices and habitual patterns of navigating lived-in space that leaves the bereaved individual at a loss as to how to go on. Examining the experience of losing a loved person and a loved person-to-be, I instead propose (...) that this breakdown should be understood primarily in relation to a distinctive kind of futurity operative in disorientation,irrespectiveof the extent to which there is a breakdown of formerly shared practices and habitual patterns of navigating lived-in space. Drawing on the resources afforded by Heidegger’s phenomenology, I argue that it is acore characteristicof the experience of disorientation in grief that the grieving person can no longer meaningfully press ahead into aspecific futural self. This view comes with certain advantages over existing accounts of the temporality of grief for making sense of the disorientated relationship to futurity, which the appeal to Heideggerian resources makes possible. (shrink)

This paper seeks to develop a phenomenological account of the disorientation of grief, specifically the relationship between disorientation and the breakdown in practical self-understanding at the heart of grief. I argue that this breakdown cannot be sufficiently understood as a breakdown of formerly shared practices and habitual patterns of navigating lived-in space that leaves the bereaved individual at a loss as to how to go on. Examining the experience of losing a loved person and a loved person-to-be, I instead propose (...) that this breakdown should be understood primarily in relation to a distinctive kind of futurity operative in disorientation, irrespective of the extent to which there is a breakdown of formerly shared practices and habitual patterns of navigating lived-in space. Drawing on the resources afforded by Heidegger’s phenomenology, I argue that it is a core characteristic of the experience of disorientation in grief that the grieving person can no longer meaningfully press ahead into a specific futural self. This view comes with certain advantages over existing accounts of the temporality of grief for making sense of the disorientated relationship to futurity, which the appeal to Heideggerian resources makes possible. (shrink)

Modern societies are characterized by a division of epistemic labor between laypeople and epistemic authorities. Authorities are often far more competent than laypeople and can thus, ideally, inform their beliefs. But how should laypeople rationally respond to an authority’s beliefs if they already have beliefs and reasons of their own concerning some subject matter? According to the standard view, the beliefs of epistemic authorities are just further, albeit weighty, pieces of evidence. In contrast, the Preemption View claims that, when one (...) discovers what an authority believes, it is not permissible to rely on any of one’s own reasons concerning the subject matter. The original version of this view, as proposed by Linda Zagzebski, has recently been severely criticized for recommending blind trust and for abandoning even minimal standards for critical thinking. In our paper, we defend a new version of the Preemption View—Defeatist Preemptionism—in a way that differs radically from Zagzebski’s. We argue that our view can be derived from certain widely accepted general epistemic principles. In particular, we claim that preemption can be identified as a special case of source sensitive defeat. Moreover, we argue that Defeatist Preemptionism does not lead to the undesirable consequences that critics ascribe to the Preemption View. The paper thus articulates the foundations and refinements of the Preemption View, such that it adequately captures the phenomenon of epistemic authority and the rational requirements related to it. (shrink)

Logical inferentialism maintains that the formal rules of inference fix the meanings of the logical terms. The categoricity problem points out to the fact that the standard formalizations of classical logic do not uniquely determine the intended meanings of its logical terms, i.e., these formalizations are not categorical. This means that there are different interpretations of the logical terms that are consistent with the relation of logical derivability in a logical calculus. In the case of the quantificational logic, the categoricity (...) problem is generated by the finite nature of the standard calculi and one direction in which it can be solved is to strengthen the deductive systems by adding infinitary rules (such as the ω-rule), i.e., to construct a full formalization. Another main direction is to provide a natural semantics for the standard rules of inference, i.e., a semantics for which these rules are categorical. My aim in this paper is to analyze some recent approaches for solving the categoricity problem and to argue that a logical inferentialist should accept the infinitary rules of inference for the first order quantifiers, since our use of the expressions “all” and “there is” leads us beyond the concrete and finite reasoning, and human beings do sometimes employ infinitary rules of inference in their reasoning. (shrink)

In this paper, I present a solution to the problem that the need to accommodate the phenomenon of epistemic defeat poses for reliabilism. Defeaters are supposed to remove justification for previously justified beliefs. According to standard process reliabilism, the justification of a belief depends on the reliability of a process that is already completed when a defeater for that belief is obtained. It is hard to see, then, how a defeater can affect reliabilist justification, if that justification, from the perspective (...) of the defeater, lies wholly in the past. What is more, undercutting defeaters plausibly defeat by generating incompatibilities with higher-order propositions :105–118, 2014; Melis in Philos Stud 170:433–442, 2014). This is hard to integrate with reliabilism which explicitly denies higher-order conditions for justification. I argue that both of these phenomena can be accommodated by it via what I call the “Replacement Principle”: when a defeater is obtained, it generates either a logical incompatibility or a doxastic incompatibility. The resulting tension is registered and initiates a reasoning process that compares the epistemic support for the defeater with that for the defeated belief. This process may replace the original reliable formation process as a doxastic base for the defeated belief. If the defeater is not given its due weight in the reasoning process, that process was unreliable and if the defeated belief is retained as a result, it will be unjustified. This is intuitively the right result. Since reasoning is reliable, only if it is rational, the account manages to capture the intuition that disregarding a defeater would be irrational without having to make rationality a condition for justification. Replacement is not only plausible on causal pictures of doxastic basing, but also required in order to allow for the possibility of belief reevaluation in general and is therefore not an ad hoc addition to reliabilism, but rather part of its inherent explanatory resources. (shrink)

An important collection of essays providing a comprehensive overview of the thought of Gilles Deleuze, one of the most influential thinkers of the twentieth century.

Interview with Constantine Sigov, dedicated to the history of the "European Dictionary of Philosophies": from the emergence of an idea in the early 90's in France until the accomplishment of the Ukrainian edition in 2019.

Vann McGee has recently argued that Belnap’s criteria constrain the formal rules of classical natural deduction to uniquely determine the semantic values of the propositional logical connectives and quantifiers if the rules are taken to be open-ended, i.e., if they are truth-preserving within any mathematically possible extension of the original language. The main assumption of his argument is that for any class of models there is a mathematically possible language in which there is a sentence true in just those models. (...) I show that this assumption does not hold for the class of models of classical propositional logic. In particular, I show that the existence of non-normal models for negation undermines McGee’s argument. (shrink)